Antibacterial
Antiviral (HIV)
Antifungal
Prevents Cancer
Potentiates the Therapeutic effects of chemotherapeutic agents against Cancer
Lowers Blood Cholesterol
Prevents Alzheimer
Exhibits potent Antiinflammatory effects
Accelerates Wound-healing
May prevent skin wrinkling/aging
Safety & Toxicity
  No significant side effects information is available so far. According to Ayurveda herbs can be taken in combination with other herbs to neutralize the intoxicity of one herb with the opposing effect of the other or to enhance the particular effect of one herb with the help of other.
   
Standardization
  Cur-500 powder extract is standardized to total cuircuminoids NLT 95% ( By spectrophotometeric method).
   
   
Anticancer properties of Cur-500
   
  :: Cur-500 inhibits tumorigenesis
  :: Cur-500 exhibits antiproliferative against cancer cell
  :: Cur-500 downregulates the activity of EGFR and expression of HER2/neu
  :: Cur-500 downregulates the activation of Nuclear Factor-KB.
  :: Cur-500 downregulates the activation of AP-1 and c-jun Kinase
  :: Cur-500 suppresses the induction of adhesion molecules
  :: Cur-500 downregulates COX-2 expression
  :: Cur-500 inhibits angiogenesis:
  :: Cur-500 suppresses the expression of matrix metalloprotease (MMP)-9 and inducible
    nitric oxide oxidase (iNOS).
  :: Cur-500 downregulates cyclin DI expression
   
Effect of Cur-500 on atheroscler and myocardial infarction.
   
  :: Cur-500 inhabits the proliferation of vascular smooth muscle cells.
  :: Cur-500 lowers serum cholesterol levels
  :: Cur-500 inhibits LDL oxidation.
  :: Cur-500 inhibits platelet aggregation.
  :: Cur-500 inhibits myocardial infarction.
   
Cur-500 suppresses diabetes
Cur-500 stimulates muscle regeneration
Cur-500 enhances wound-dealing.
Cur-500 suppresses symptoms associated with arthritis.
Cur-500 reduces the incidence of cholesterol gall-stones (CGS) formation
Cur-500 modulates multiple sclerosis
Cur-500 blocks the replication of HIV
Cur-500 affects Alzheimer's disease
Cur-500 protects against cataract formation in lenses
Cur-500 protects from drug-induced myocardial toxicity
Cur-500 protects from drug-induced lung injury
Cur-500 protects from drug-induced nephrotoxicity
Cur-500 helps in stopping the spread of breast cancer, tumor cells to the lungs
   
Dosage
  Healthy people should take one capsule, once or twice daily with meals.Or as directed by the physician.
   
Caution
  Always take with meals because curcumin can cause gastric irritation and ulceration , if taken on empty stomach.
   
Clinical Trail
  A clinical trail with Turmeric was conducted in 114 patients of respiratory diseases consisting 71 cases of bronchitis, 13 cases of bronchiectasis, 18 cases of bronchial asthma and 12 cases of tropical eosinophilia. Drug was administered in gradually increasing doses from 4 to 32 gm daily for a period of 15 to 45 days. Significant improvement in signs and relief in airway resistance was observed in 11 cases of bronchitis, 1 case of bronchiectasis, 5 cases of bronchial asthma and 6 cases of tropical eosinophilia.
   
References
  Ammon HP, wahi MA. Pharmacology of Curcuma longa. planta Med 1991;57:1-7
  Cheng AL, hsu CJl, LIn JK, et al. Phase I clinical trial of curcumin, a chemopreventive
    agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001; 21 :
    2895-2900.
  Clinical development plan: curcumin. J cell Biochem Suppl 1996; 26:72-85
  Huang MT, wang ZY, Georgiadis CA, Laskin JD, Conny AH, Inhibitory effects of curcumin
    on tumor initiation by benzo[a]pyrene and 7,12 dimethylbenz[a]anthracene-induced.
    Carcinogenesis 1992;13:2183-2186.
  Han SS, Chung ST, Robertson DA, Ranjan D, Bondada S. lymphoma by downregulation
    of egr-l, c-myc, bel-XL, NF-kappa B, and p53. Clin lmmunol 1999; 93:152-161
  Ramachandran C, You w. Differential sensitivity of human mammary epithelial and
    breast carcinoma cell lines to curcumin. Breast Cancer Res Treat 1999; 54:269-278.
  Conney AH, Lysz T, Ferraro T, et al. Inhibitory effect of curcumin and some related
   dietary compunds on tumor promotion and arachidonic acid metabolism in mouse skin.
   Adv Enzyme Regul 1991; 31:385-396.
  Rao CV, Rivenson A, Simi B, Reddy BS. Chemoprevention of colon carcinogenesis by
   dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res 1995;
   55:259-266.
   
  NOTE: These statements have not been evaluated by the Food and Drug Administration, This product is not intended to diagnose treat, cure or prevent any disease.
   
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